Prediction of Solid-liquid-vapor Equilibrium for Supercritical Processing of Pharmaceuticals Using a Cubic Equation of State and Group Contribution Methods
نویسنده
چکیده
In this work is examined whether it is possible to predict solid-liquid-vapor phase equilibrium of ternary systems used in the SAS processing by the Peng-Robinson equation of state coupled with the LCVM mixing rules and the UNIFAC method for excess Gibbs free energy calculation. The enthalpy of fusion and the melting point temperature are estimated by group contribution methods. The results show a good agreement between experimental and calculated data and the main conclusion is that the PR-LCVM can be used in a totally predictive way. As a consequence, this EOS can be used to monitor the behavior of the antisolvent molar fraction as a function of the ternary mixture solid-liquid-vapor phase equilibrium.
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